Preheat the oven: Preheat the oven to 425°F (220°C).
Prepare the cauliflower: Rinse the cauliflower florets and pat them dry with a paper towel.
Mix the Parmesan and breadcrumbs: In a bowl, mix together the Parmesan cheese and breadcrumbs.
Toss the cauliflower with oil and seasonings: In a separate bowl, toss the cauliflower florets with olive oil, salt, black pepper, garlic powder, Italian seasoning, and red pepper flakes (if using).
Coat the cauliflower with Parmesan mixture: Add the Parmesan and breadcrumb mixture to the cauliflower and toss to coat evenly.
Spread the cauliflower on a baking sheet: Spread the cauliflower florets on a baking sheet in a single layer.
Roast the cauliflower: Roast the cauliflower in the preheated oven for 20-25 minutes, or until crispy and golden brown.
Serve: Serve the crispy Parmesan roasted cauliflower hot, garnished with chopped fresh parsley (if desired).